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ttna Δ9/Δ9 adult zebrafish exhibit atrial fibrillation (AF), and both ttna Δ9/Δ9 zebrafish atrial cardiomyocytes and TTN Δ9/Δ9 -hiPSC-aCMs demonstrate abnormal electrophysiology (A) Representative <t>electrocardiogram</t> <t>(ECG)</t> recordings of 7–15-months-old ttna +/+ ( n = 20), ttna Δ9/Δ9 ( n = 17), and ttna Δ9/Δ9 ( n = 27) zebrafish hearts. Upper panel: ttna +/+ <t>ECG</t> trace; middle panel: ttna Δ9/+ ECG trace; lower panel: ttna Δ9/Δ9 ECG trace demonstrating P-wave loss and arrhythmia. (B) Quantification of AF incidence in ttna +/+ , ttna Δ9/+ , and ttna Δ9/Δ9 adult zebrafish. (C) Quantification of heartbeat interval standard deviation in zebrafish with AF in comparison to ttna +/+ adults. (D) Representative recordings of action potential (AP) on isolated ttna +/+ ( n = 5) and ttna Δ9/Δ9 ( n = 6) zebrafish atrial cardiomyocytes at 12 months of age. (E) Quantification of AP duration at 90% repolarization (APD 90 ) in isolated zebrafish atrial cardiomyocytes. (F) Representative optical AP recordings of TTN +/+ -hiPSC-aCMs and TTN Δ9/Δ9 -hiPSC-aCMs with voltage-sensitive dye VF2.1Cl. (G) Quantification of APD 90 in hiPSC-aCMs ( n = 4 independent batches, n = 5–6 biological replicates per batch). Data in (C, E, and G) are represented as mean ±95% confidence intervals. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. See also <xref ref-type=Figure S8 . " width="250" height="auto" />
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ttna Δ9/Δ9 adult zebrafish exhibit atrial fibrillation (AF), and both ttna Δ9/Δ9 zebrafish atrial cardiomyocytes and TTN Δ9/Δ9 -hiPSC-aCMs demonstrate abnormal electrophysiology (A) Representative <t>electrocardiogram</t> <t>(ECG)</t> recordings of 7–15-months-old ttna +/+ ( n = 20), ttna Δ9/Δ9 ( n = 17), and ttna Δ9/Δ9 ( n = 27) zebrafish hearts. Upper panel: ttna +/+ <t>ECG</t> trace; middle panel: ttna Δ9/+ ECG trace; lower panel: ttna Δ9/Δ9 ECG trace demonstrating P-wave loss and arrhythmia. (B) Quantification of AF incidence in ttna +/+ , ttna Δ9/+ , and ttna Δ9/Δ9 adult zebrafish. (C) Quantification of heartbeat interval standard deviation in zebrafish with AF in comparison to ttna +/+ adults. (D) Representative recordings of action potential (AP) on isolated ttna +/+ ( n = 5) and ttna Δ9/Δ9 ( n = 6) zebrafish atrial cardiomyocytes at 12 months of age. (E) Quantification of AP duration at 90% repolarization (APD 90 ) in isolated zebrafish atrial cardiomyocytes. (F) Representative optical AP recordings of TTN +/+ -hiPSC-aCMs and TTN Δ9/Δ9 -hiPSC-aCMs with voltage-sensitive dye VF2.1Cl. (G) Quantification of APD 90 in hiPSC-aCMs ( n = 4 independent batches, n = 5–6 biological replicates per batch). Data in (C, E, and G) are represented as mean ±95% confidence intervals. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. See also <xref ref-type=Figure S8 . " width="250" height="auto" />
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ttna Δ9/Δ9 adult zebrafish exhibit atrial fibrillation (AF), and both ttna Δ9/Δ9 zebrafish atrial cardiomyocytes and TTN Δ9/Δ9 -hiPSC-aCMs demonstrate abnormal electrophysiology (A) Representative <t>electrocardiogram</t> <t>(ECG)</t> recordings of 7–15-months-old ttna +/+ ( n = 20), ttna Δ9/Δ9 ( n = 17), and ttna Δ9/Δ9 ( n = 27) zebrafish hearts. Upper panel: ttna +/+ <t>ECG</t> trace; middle panel: ttna Δ9/+ ECG trace; lower panel: ttna Δ9/Δ9 ECG trace demonstrating P-wave loss and arrhythmia. (B) Quantification of AF incidence in ttna +/+ , ttna Δ9/+ , and ttna Δ9/Δ9 adult zebrafish. (C) Quantification of heartbeat interval standard deviation in zebrafish with AF in comparison to ttna +/+ adults. (D) Representative recordings of action potential (AP) on isolated ttna +/+ ( n = 5) and ttna Δ9/Δ9 ( n = 6) zebrafish atrial cardiomyocytes at 12 months of age. (E) Quantification of AP duration at 90% repolarization (APD 90 ) in isolated zebrafish atrial cardiomyocytes. (F) Representative optical AP recordings of TTN +/+ -hiPSC-aCMs and TTN Δ9/Δ9 -hiPSC-aCMs with voltage-sensitive dye VF2.1Cl. (G) Quantification of APD 90 in hiPSC-aCMs ( n = 4 independent batches, n = 5–6 biological replicates per batch). Data in (C, E, and G) are represented as mean ±95% confidence intervals. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. See also <xref ref-type=Figure S8 . " width="250" height="auto" />
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ttna Δ9/Δ9 adult zebrafish exhibit atrial fibrillation (AF), and both ttna Δ9/Δ9 zebrafish atrial cardiomyocytes and TTN Δ9/Δ9 -hiPSC-aCMs demonstrate abnormal electrophysiology (A) Representative <t>electrocardiogram</t> <t>(ECG)</t> recordings of 7–15-months-old ttna +/+ ( n = 20), ttna Δ9/Δ9 ( n = 17), and ttna Δ9/Δ9 ( n = 27) zebrafish hearts. Upper panel: ttna +/+ <t>ECG</t> trace; middle panel: ttna Δ9/+ ECG trace; lower panel: ttna Δ9/Δ9 ECG trace demonstrating P-wave loss and arrhythmia. (B) Quantification of AF incidence in ttna +/+ , ttna Δ9/+ , and ttna Δ9/Δ9 adult zebrafish. (C) Quantification of heartbeat interval standard deviation in zebrafish with AF in comparison to ttna +/+ adults. (D) Representative recordings of action potential (AP) on isolated ttna +/+ ( n = 5) and ttna Δ9/Δ9 ( n = 6) zebrafish atrial cardiomyocytes at 12 months of age. (E) Quantification of AP duration at 90% repolarization (APD 90 ) in isolated zebrafish atrial cardiomyocytes. (F) Representative optical AP recordings of TTN +/+ -hiPSC-aCMs and TTN Δ9/Δ9 -hiPSC-aCMs with voltage-sensitive dye VF2.1Cl. (G) Quantification of APD 90 in hiPSC-aCMs ( n = 4 independent batches, n = 5–6 biological replicates per batch). Data in (C, E, and G) are represented as mean ±95% confidence intervals. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. See also <xref ref-type=Figure S8 . " width="250" height="auto" />
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ttna Δ9/Δ9 adult zebrafish exhibit atrial fibrillation (AF), and both ttna Δ9/Δ9 zebrafish atrial cardiomyocytes and TTN Δ9/Δ9 -hiPSC-aCMs demonstrate abnormal electrophysiology (A) Representative <t>electrocardiogram</t> <t>(ECG)</t> recordings of 7–15-months-old ttna +/+ ( n = 20), ttna Δ9/Δ9 ( n = 17), and ttna Δ9/Δ9 ( n = 27) zebrafish hearts. Upper panel: ttna +/+ <t>ECG</t> trace; middle panel: ttna Δ9/+ ECG trace; lower panel: ttna Δ9/Δ9 ECG trace demonstrating P-wave loss and arrhythmia. (B) Quantification of AF incidence in ttna +/+ , ttna Δ9/+ , and ttna Δ9/Δ9 adult zebrafish. (C) Quantification of heartbeat interval standard deviation in zebrafish with AF in comparison to ttna +/+ adults. (D) Representative recordings of action potential (AP) on isolated ttna +/+ ( n = 5) and ttna Δ9/Δ9 ( n = 6) zebrafish atrial cardiomyocytes at 12 months of age. (E) Quantification of AP duration at 90% repolarization (APD 90 ) in isolated zebrafish atrial cardiomyocytes. (F) Representative optical AP recordings of TTN +/+ -hiPSC-aCMs and TTN Δ9/Δ9 -hiPSC-aCMs with voltage-sensitive dye VF2.1Cl. (G) Quantification of APD 90 in hiPSC-aCMs ( n = 4 independent batches, n = 5–6 biological replicates per batch). Data in (C, E, and G) are represented as mean ±95% confidence intervals. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. See also <xref ref-type=Figure S8 . " width="250" height="auto" />
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ttna Δ9/Δ9 adult zebrafish exhibit atrial fibrillation (AF), and both ttna Δ9/Δ9 zebrafish atrial cardiomyocytes and TTN Δ9/Δ9 -hiPSC-aCMs demonstrate abnormal electrophysiology (A) Representative <t>electrocardiogram</t> <t>(ECG)</t> recordings of 7–15-months-old ttna +/+ ( n = 20), ttna Δ9/Δ9 ( n = 17), and ttna Δ9/Δ9 ( n = 27) zebrafish hearts. Upper panel: ttna +/+ <t>ECG</t> trace; middle panel: ttna Δ9/+ ECG trace; lower panel: ttna Δ9/Δ9 ECG trace demonstrating P-wave loss and arrhythmia. (B) Quantification of AF incidence in ttna +/+ , ttna Δ9/+ , and ttna Δ9/Δ9 adult zebrafish. (C) Quantification of heartbeat interval standard deviation in zebrafish with AF in comparison to ttna +/+ adults. (D) Representative recordings of action potential (AP) on isolated ttna +/+ ( n = 5) and ttna Δ9/Δ9 ( n = 6) zebrafish atrial cardiomyocytes at 12 months of age. (E) Quantification of AP duration at 90% repolarization (APD 90 ) in isolated zebrafish atrial cardiomyocytes. (F) Representative optical AP recordings of TTN +/+ -hiPSC-aCMs and TTN Δ9/Δ9 -hiPSC-aCMs with voltage-sensitive dye VF2.1Cl. (G) Quantification of APD 90 in hiPSC-aCMs ( n = 4 independent batches, n = 5–6 biological replicates per batch). Data in (C, E, and G) are represented as mean ±95% confidence intervals. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. See also <xref ref-type=Figure S8 . " width="250" height="auto" />
Customized Encased Waterproof 3 Channel Holter Ecg Recorder H Scribe V4.34 Software, supplied by Mortara Instrument, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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customized-encased waterproof 3-channel holter ecg recorder h-scribe v4.34 software - by Bioz Stars, 2026-10
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ttna Δ9/Δ9 adult zebrafish exhibit atrial fibrillation (AF), and both ttna Δ9/Δ9 zebrafish atrial cardiomyocytes and TTN Δ9/Δ9 -hiPSC-aCMs demonstrate abnormal electrophysiology (A) Representative electrocardiogram (ECG) recordings of 7–15-months-old ttna +/+ ( n = 20), ttna Δ9/Δ9 ( n = 17), and ttna Δ9/Δ9 ( n = 27) zebrafish hearts. Upper panel: ttna +/+ ECG trace; middle panel: ttna Δ9/+ ECG trace; lower panel: ttna Δ9/Δ9 ECG trace demonstrating P-wave loss and arrhythmia. (B) Quantification of AF incidence in ttna +/+ , ttna Δ9/+ , and ttna Δ9/Δ9 adult zebrafish. (C) Quantification of heartbeat interval standard deviation in zebrafish with AF in comparison to ttna +/+ adults. (D) Representative recordings of action potential (AP) on isolated ttna +/+ ( n = 5) and ttna Δ9/Δ9 ( n = 6) zebrafish atrial cardiomyocytes at 12 months of age. (E) Quantification of AP duration at 90% repolarization (APD 90 ) in isolated zebrafish atrial cardiomyocytes. (F) Representative optical AP recordings of TTN +/+ -hiPSC-aCMs and TTN Δ9/Δ9 -hiPSC-aCMs with voltage-sensitive dye VF2.1Cl. (G) Quantification of APD 90 in hiPSC-aCMs ( n = 4 independent batches, n = 5–6 biological replicates per batch). Data in (C, E, and G) are represented as mean ±95% confidence intervals. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. See also <xref ref-type=Figure S8 . " width="100%" height="100%">

Journal: iScience

Article Title: Transient titin-dependent ventricular defects during development lead to adult atrial arrhythmia and impaired contractility

doi: 10.1016/j.isci.2024.110395

Figure Lengend Snippet: ttna Δ9/Δ9 adult zebrafish exhibit atrial fibrillation (AF), and both ttna Δ9/Δ9 zebrafish atrial cardiomyocytes and TTN Δ9/Δ9 -hiPSC-aCMs demonstrate abnormal electrophysiology (A) Representative electrocardiogram (ECG) recordings of 7–15-months-old ttna +/+ ( n = 20), ttna Δ9/Δ9 ( n = 17), and ttna Δ9/Δ9 ( n = 27) zebrafish hearts. Upper panel: ttna +/+ ECG trace; middle panel: ttna Δ9/+ ECG trace; lower panel: ttna Δ9/Δ9 ECG trace demonstrating P-wave loss and arrhythmia. (B) Quantification of AF incidence in ttna +/+ , ttna Δ9/+ , and ttna Δ9/Δ9 adult zebrafish. (C) Quantification of heartbeat interval standard deviation in zebrafish with AF in comparison to ttna +/+ adults. (D) Representative recordings of action potential (AP) on isolated ttna +/+ ( n = 5) and ttna Δ9/Δ9 ( n = 6) zebrafish atrial cardiomyocytes at 12 months of age. (E) Quantification of AP duration at 90% repolarization (APD 90 ) in isolated zebrafish atrial cardiomyocytes. (F) Representative optical AP recordings of TTN +/+ -hiPSC-aCMs and TTN Δ9/Δ9 -hiPSC-aCMs with voltage-sensitive dye VF2.1Cl. (G) Quantification of APD 90 in hiPSC-aCMs ( n = 4 independent batches, n = 5–6 biological replicates per batch). Data in (C, E, and G) are represented as mean ±95% confidence intervals. ∗ p < 0.05; ∗∗ p < 0.01; ∗∗∗ p < 0.001. See also Figure S8 .

Article Snippet: LabScribe ECG recording software , iWorx , https://iworx.com/labscribe/?v=7516fd43adaa.

Techniques: Standard Deviation, Comparison, Isolation

Journal: iScience

Article Title: Transient titin-dependent ventricular defects during development lead to adult atrial arrhythmia and impaired contractility

doi: 10.1016/j.isci.2024.110395

Figure Lengend Snippet:

Article Snippet: LabScribe ECG recording software , iWorx , https://iworx.com/labscribe/?v=7516fd43adaa.

Techniques: Recombinant, Hybridization, SYBR Green Assay, Control, Software, Imaging, Microscopy